This is not an essay, this is a discussion assignment I attached word file. There is 3 different writings from students I want you to reply to each of them and aim for at least 50 words in each . Read the guidelines and get the idea what to include in your writing.. FIRST ONE TO REACT AND REPLY TO :

Chronic Asthma and Cell Extrusion

The problems associated with Lungs is believed to be triggered due to different irritants and pollutants that is inhaled and passed through the airways into the system of living beings including human. The irritants create discomfort in the bronchioles, causes inflammation of airways which can eventually affect the lining of the lungs also known as epithelial lung cells. When epithelial lung cells have trouble, the cells in the lining start to replicate and create more cells which increases the number of cells. The increased cell population adds pressure to the tissue and cells create pressure. This is when the functioning system comes into action by forcefully removing weaker cells and maintaining a balance. However, if problems associated with lungs intensify, such as to moderate or severe asthma, this process of cell replication and balance might be overworked which might lead to other problems. As stated by Jody Rosenblatt in her research in 2015, that the pressure from overcrowding in the epithelium could trigger cell death and extrusion and she had a valid point where she questions if the pressure from a single asthma attack can create the cycle of cell death causing damage to the lungs and other asthma attacks (Brouilette, 2024).

The media article by Brouilette (2024) focuses on chronic asthma can be a result of cell overcrowding in the airways. The author explains cell extrusion and how it maintains a healthy epithelial lining but also raises questions through Jody Rosenblatt’s research about how this vicious cycle might create other problems in the lungs in the future. The media article also mentions the research that was performed with Metacholine and Albuterol. Metacholine tested Jody’s question of vicious cycle that might arise if cell extrusion is repeatedly performed while Albuterol made breathing easier but did not help to reverse the damage. The article also mentions ongoing research on protein peiozo1, and how more research is needed to check if this method helps prevent damage to the lungs.

On the other hand, academic journal by Bagley et al., (2024), talks about bronchoconstriction and its damage while also mentioning some research done on live cell extrusion and how it seems to be helpful in preventing the damage during cell extrusion. Another academic article by Eisenhoffer et al., (2012), provides further details on apoptosis (programmed cell death), the role of actomyosin ring to bring the dead cells out of the system. The article also talks about experimentally overcrowding monolayers in vitro along with live cell extrusion and the important role of sphingosine and rhokinase dependent myosin contraction using stretch activated channel using protein peizo1. The article explains the research performed with stretch activated channel which can prevent tumour by preventing excess cell extrusion.

I, personally, after reading these academic and media articles, can say use of peizo1 through stretch activated channel seems more beneficial when compared to other methods used to treat asthma in the past. Although, more research and conclusions are yet to be made on this specific treating method but these articles make me more hopeful for the cure of asthma and other lung problems in the future without much sever damage and curing the source not only the symptoms.

References:

• Brouilette, M. (2024). Health and Medicine: Chronic asthma could be caused by cell overcrowding in the airways. Retrieved from – https://www.sciencenews.org/article/chronic-asthma-cell-overcrowding-airway

• Bagley, D., Russell, T., Ortiz-Zapater, E., Stinson, S., Fox, K., Redd, P., & Rosenblatt, J (2024). Bronchoconstriction damages airway epithelia by crowding-induced excess cell extrusion. Retrieved from – https://www.science.org/doi/10.1126/science.adk2758

• Eisenhoffer, G., Loftus, P., Yoshigi, M., Otsuna, H., Chien, C., Morcos, P., Rosenblatt, J (2012). Crowding induces live cell extrusion to maintain homeostatic cell numbers in epithelia. Retrieved from – https://pubmed.ncbi.nlm.nih.gov/22504183/

SECOND ONE TO REACT AND REPLY TO :

I have chosen an article by Science Daily that discusses a therapy that is designed to kill hyper virulent bacteria. Fleeman claims that bacteria are becoming resistant to antibiotics and even states that by the year 2050, “antibiotic resistant bacterial infections will be the number one cause of human deaths”. This not only will this affect general medication for common antibiotic use, but it jeopardizes cancer therapy, as well as organ transplants. Research has presented a antimicrobial peptide derived from cows that might be the solution. Looking at both the media article and scientific journal, there wasn’t a big of difference in content. However, I definitely see a difference in key audiences. For example in the scientific journal, the abstract that gives insight to the reading, states that there’s a “peptide from cows that has potential for treating incurable infections.” While in the medial article the abstract reads “study has identified a therapy that can penetrate the slime that such infections use to protect themselves from antibiotics.” To me the scientific journal’s abstract has a more general audience appeal than the blunt facts from the media article. The writing of the media article is more for the science base knowledge demographic due to the use of proper terminology such as (biofilm and bacteria chain structure), as well as the names of the specific bacteria such as klebsiella pneuoniae. Overall the key difference between a medial article and scientific journal, is the proper and formality of the writing, correlating to the key audiences.

http://www.sciencedaily.com/releases/2024/05/240502113626.htm

http://www.ucf.edu/news/medical-school-scientist-creates-therapy-to-kill-hypervirulent-bactieria/

THIRD ONE TO REACT AND REPLY TO :

I chose to discuss the article on ScienceDaily, “Genetics, not lack of oxygen, causes cerebral palsy in quarter of cases”. It is a journal that focuses on the discovery of genetic defects being more likely responsible for cerebral palsy (CP), rather than a lack of oxygen at birth, as it was previously thought. The research focuses on cases involving Chinese children. It is informative on genetic variations linked to cerebral palsy. The media article goes more into the depth of research done and explanation of what other birth defects, like asphyxia” are diagnosed with CP. It informs the reader of the effects cerebral palsy has on children. Also, emphasizes that it is the most prevalent motor disability in children. The Journal article is very brief and straight to the point. It provides statistics which I enjoyed. Overall, the academic journal article lacks a deeper understanding of cerebral palsy and does not provide information on future research directions like the article provided.

Media Article: Genetics, not lack of oxygen, causes cerebral palsy in quarter of cases | ScienceDaily

Journal: Exome sequencing reveals genetic heterogeneity and clinically actionable findings in children with cerebral palsy | Nature Medicine